Sytems thinking is a new paradigm shift in approach to tackle problems. I have earlier written a post introducing application of systems approach to medicine here. I once mailed Leroy Hood, my favourite scientist and the best systems biologist, on how should I prepare myself for systems medicine during my undergraduate years. Surprisingly, he replied within a day. This is what he advised,
Sachin–I believe that the best training for systems medicine (and P4 medicine) is to obtain a good cross-disciplinary background. I would, for example, focus on biology and one other orthogonal discipline such as computer science or applied physics. I would be certain to have a good back ground in math, physics and chemistry. I would certainly learn statistics. You need to be familiar in a general way with bioinformatics and its powerful tools. I am certain this sounds challenging–and it is. But it place you in a unique position to attack the big problems of systems science.
I will send you a couple of papers you may find interesting.
Best of luck,